Spatial learning and memory deficits in IP₃K-A Tg mice.

<p>In the open-field test, WT and IP₃K-A Tg mice showed no difference in total distance traveled (A) and time spent exploring the margins or the center of the field (B) (WT, n = 11; Tg, n = 10). (C), However, IP₃K-A Tg mice showed a mild impairment in object recognition memory. Mice were exposed to two identical or different objects (A-A, A-B, and A-C) during the sample, 24 h retention, and 72 h retention trials, respectively. The percentage of the total time that was spent investigating the novel object during each trial period was quantified as the preference percentage (WT, n = 11; Tg, n = 10). (D and E), Compared with WT mice, Tg mice showed increased error rates in the radial arm maze test. Tg mice tended to show a higher error rate in early sessions (S1–S3) (D) and showed a significant higher error rate in early phase (S1–S3), but not late phase (S4–S7) (E) (WT, n = 15; Tg, n = 12).