Impaired temporal order object discrimination memory and spatial location memory in Akt3-deficient mice.

<p>(a) Discrimination ratio displayed by Akt3-deficient mice during the 5 min test phase (sample 3) of the temporal order object recognition task. (** p≤0.01 by posthoc LSD; n = 14 WT, 28 Het, 7 KO). (b) Total time spent exploring the objects presented during the 5-min sample phases 1, 2 and 3. (c) Discrimination ratio for the novel object by Akt3-deficient mice during the novel object test (n = 9 WT, 11 Het, 7 KO). (d) Time spent exploring the two objects during the 10 min acquisition session and the 5 min retention session of the novel object recognition test. (e) Discrimination ratio for the moved object over the same-placed object (**p≤0.01; n = 9 WT, 10 Het, 6 KO). (f) Time spent exploring the two objects during the 10 min acquisition and the 5 min test session of the same object location test. (g) Absence of differences in baseline movement (Nulstim) or Startle responses in the pre-pulse inhibition test in Akt3-deficient mice. (n = 18 WT, 26 Het, 8 KO). (h) Percentage prepulse inhibition of the acoustic startle response displayed by the same mice after the presentation of prepulse (n = 18 WT, 26 Het, 8 KO). Data bars represent the mean, with individual data points representing individual subject measures.