The impaired working memory and spatial memory in α2AP^−/− mice compared with WT mice.

<p>The Y-maze test showed that there was little effect of the α2AP deficiency on the spontaneous behavior of the mice (A), but the working memory was impaired in the α2AP^−/− mice compared with WT mice (B) (WT and α2AP^−/− mice, n = 12 and 8, respectively). The results of the training sessions are shown in C. The number of crossings in each quadrant and the number of crossings over the platform in the probe test are shown in D and E, respectively. The Morris water maze test showed that α2AP^−/− mice exhibited impairments in their spatial memory (C–E) (n = 8). The values represent the means±S.E. Significance was evaluated using Student’s <i>t</i>-test or an ANOVA with a LSD post-hoc test. *P<0.05, **P<0.01.