Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L-0

<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L"</p><p>http://www.biomedcentral.com/1471-213X/7/104</p><p>BMC Developmental Biology 2007;7():104-104.</p><p>Published online 18 Sep 2007</p><p>PMCID:PMC2212652.</p><p></p>lls do not appear to be entering meiosis in the absence of DNMT3L (right panel). Immunoperoxidase staining of germ cells with the GCNA1 antibody (brown) in testis sections of 10 dpp (top) and 8 dpp (bottom) and mice. Graphical representation of germ cell counts in and testes. A difference in germ cell count is observed as early as 6 dpp in absence of DNMT3L. By 10 dpp, mutant males have approximately a quarter of the number of germ cells their littermates have. For each time point, GCNA1-positive germ cells were counted per 2000 Sertoli cells; two to three males were examined per genotype. Results are presented as means ± SEM; mean counts for individual males are presented as dots when only two animals were analyzed