Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L-4

<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L"</p><p>http://www.biomedcentral.com/1471-213X/7/104</p><p>BMC Developmental Biology 2007;7():104-104.</p><p>Published online 18 Sep 2007</p><p>PMCID:PMC2212652.</p><p></p>nzyme assay, quantitative analysis of methylation PCR or qAMP [44]. Analysis of established DMR regions of three known paternally methylated imprinted genes, (top left), (top right) and (bottom left), and one known maternally methylated imprinted gene, (bottom right). At least one site of and is affected in the two samples analyzed, whereas methylation remains unchanged. Three different enzymes were used in qAMP: HhaI (white), McrBC (black) and NotI (grey)