Background: Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA methylation pattern acquisition during gametogenesis remains unclear. Here we report on the role of DNMT3L in male germ cell development. Results: A developmental study covering the first 12 days following birth was conducted on a Dnmt3L mutant mouse model; lower germ cell numbers and delayed entry into meiosis were observed in Dnmt3L-/- males, pointing to a mitotic defect. A temporal expression study showed that expression of Dnmt3L is highest in prenatal gonocytes but is also detected and d...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrate...
AbstractIn the male germ line, sequence-specific methylation patterns are initially acquired prenata...
SummaryA critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation....
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
AbstractThe acquisition of genomic methylation in the male germ line is initiated prenatally in dipl...
AbstractThe development of germ cells is a highly ordered process that begins during fetal growth an...
The production of mature germ cells capable of generating totipotent zygotes is a highly specialized...
Background: Normal mammalian development requires the action of DNA methyltransferases (DNMTs) for t...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
Background: DNA methylation is an epigenetic modification involved in gene expression, genome stabil...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
DNA methylation, associated with gene or transposable element (TE) repression, plays a key role in s...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrate...
AbstractIn the male germ line, sequence-specific methylation patterns are initially acquired prenata...
SummaryA critical aspect of mammalian gametogenesis is the reprogramming of genomic DNA methylation....
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
AbstractThe acquisition of genomic methylation in the male germ line is initiated prenatally in dipl...
AbstractThe development of germ cells is a highly ordered process that begins during fetal growth an...
The production of mature germ cells capable of generating totipotent zygotes is a highly specialized...
Background: Normal mammalian development requires the action of DNA methyltransferases (DNMTs) for t...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
Background: DNA methylation is an epigenetic modification involved in gene expression, genome stabil...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
DNA methylation, associated with gene or transposable element (TE) repression, plays a key role in s...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
<p><b>Copyright information:</b></p><p>Taken from "Loss of spermatogonia and wide-spread DNA methyla...
Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrate...