Incubated at 37°C in COatmosphere with increasing concentrations of SP4-2, as indicated, then infected with either X4-tropic NL4-3 (panel A, a-d) or with R5-tropic 81A (panel B, e-h), at 0.3 moi, in replicates (n = 4). 48 h after infection cells were quantified by FACS, and % infected cells is shown on each panel. Uninfected and untreated control (mock) is superimposed over each graph in dotted line. Representative of 4 experiments.<p><b>Copyright information:</b></p><p>Taken from "fraction is a potent and specific inhibitor of HIV-1 fusion and reverse transcriptase"</p><p>http://www.virologyj.com/content/5/1/8</p><p>Virology Journal 2008;5():8-8.</p><p>Published online 15 Jan 2008</p><p>PMCID:PMC2267448.</p><p></p
<p>MT-4 cells were infected with HIV-1(III<sub>B</sub>) for 1 h after which the cells were washed an...
(a) Representative FACS dot plots of TRIM5-KO or control Jurkat cells infected or not with AT-2- or ...
<p>(A) Tissues from a representative non-treated control mouse (#1) showed the presence of productiv...
Tmosphere with increasing concentrations of SP4-2 for 1.5 hours prior to infection. Treatment was wa...
10M ddC, or mock treated (0 μg SP4-2), as indicated. Then, cells were infected with HIV-1 (NL4-3) at...
10M ddC, or mock treated (0 μg SP4-2), as indicated. Then, cells were infected with HIV-1 (NL4-3) at...
M-Vpr-X4-tropic NL4-3, or (C) infected in the presence of 10 μg/ml SP4-2, or (D) infected in the pre...
1 chimera NL4-3 EnvLuc/VSV-G pseudotype, washed 3 times, and then treated with increasing concentrat...
(a) Representative two-color dot plots of T5KO and control (CAG) Jurkat cells infected first with B2...
<p>(A) Titration of PF74 or indicated derivatives onto HeLa cells infected with VSV-G pseudotyped GF...
<p><i>A</i>, Comparison of time-of-addition (TOA) profiles of PS extract and reference compounds tha...
<p>+/- values represent the standard errors of triplicates. Results are representative of two indepe...
<p>A) HIV-1 viral fusion in PSC-macrophages. The percentage of fusion of HIV-1 virions was normalise...
<p>Inhibition of HIV-1 infection by PS extract was enhanced by pre-incubation of virus preparations ...
<p>The fraction neutralized is plotted against the concentration of Fab sites. The inserts in A, B a...
<p>MT-4 cells were infected with HIV-1(III<sub>B</sub>) for 1 h after which the cells were washed an...
(a) Representative FACS dot plots of TRIM5-KO or control Jurkat cells infected or not with AT-2- or ...
<p>(A) Tissues from a representative non-treated control mouse (#1) showed the presence of productiv...
Tmosphere with increasing concentrations of SP4-2 for 1.5 hours prior to infection. Treatment was wa...
10M ddC, or mock treated (0 μg SP4-2), as indicated. Then, cells were infected with HIV-1 (NL4-3) at...
10M ddC, or mock treated (0 μg SP4-2), as indicated. Then, cells were infected with HIV-1 (NL4-3) at...
M-Vpr-X4-tropic NL4-3, or (C) infected in the presence of 10 μg/ml SP4-2, or (D) infected in the pre...
1 chimera NL4-3 EnvLuc/VSV-G pseudotype, washed 3 times, and then treated with increasing concentrat...
(a) Representative two-color dot plots of T5KO and control (CAG) Jurkat cells infected first with B2...
<p>(A) Titration of PF74 or indicated derivatives onto HeLa cells infected with VSV-G pseudotyped GF...
<p><i>A</i>, Comparison of time-of-addition (TOA) profiles of PS extract and reference compounds tha...
<p>+/- values represent the standard errors of triplicates. Results are representative of two indepe...
<p>A) HIV-1 viral fusion in PSC-macrophages. The percentage of fusion of HIV-1 virions was normalise...
<p>Inhibition of HIV-1 infection by PS extract was enhanced by pre-incubation of virus preparations ...
<p>The fraction neutralized is plotted against the concentration of Fab sites. The inserts in A, B a...
<p>MT-4 cells were infected with HIV-1(III<sub>B</sub>) for 1 h after which the cells were washed an...
(a) Representative FACS dot plots of TRIM5-KO or control Jurkat cells infected or not with AT-2- or ...
<p>(A) Tissues from a representative non-treated control mouse (#1) showed the presence of productiv...