Kindlin-2 is required for myocyte elongation and is essential for myogenesis-8

Nti-paxillin (red) on C2C12 cells transfected with RNAi and then changed to differentiation media for 2 days. Control cells (scr RNAi) show linear staining consistent with localization to costameres (arrows), as well as punctate focal contact staining (arrowheads). Conversely, focal contact proteins in the kindlin-2 RNAi cells fail to form linear structures and instead are concentrated in unusual appearing puncta (*). (Scale bar = 20 μM). B. Oregon Green phalloidin staining on day 2 differentiated C2C12 cells. In the scrambled RNAi myocytes, actin is found primarily in a linear, fiber like pattern. Conversely, in the kindlin-2 RNAi cells it is found concentrated at the membrane. (Scale bar = 20 μM).<p><b>Copyright information:</b></p><p>Taken from "Kindlin-2 is required for myocyte elongation and is essential for myogenesis"</p><p>http://www.biomedcentral.com/1471-2121/9/36</p><p>BMC Cell Biology 2008;9():36-36.</p><p>Published online 8 Jul 2008</p><p>PMCID:PMC2478659.</p><p>