DC bone marrow progenitors are unaltered in absence of Pin1.

<p>(A) Normalization of total bone marrow cells from WT and Pin1-null mice by weight (grams). WT and Pin1-null mice were weighed upon euthanization. The normalized graph was generated by dividing the total number of bone marrow cells by the body weight (grams) of each mouse (n = 6). (B) Quantitation of normalized numbers of bone marrow progenitors in both WT and Pin1-null mice. KLS, c-kit+Lin-sca1+ stem cells; CLP, common lymphoid progenitor; CMP, common myeloid progenitor; GMP, granulocyte-macrophage progenitor; MDP, macrophage-dendritic cell progenitor; CDP, common dendritic cell progenitor. Total cell numbers were determined by multiplying the frequency of each population by the total number of bone marrow cells. Total population numbers were then normalized to body weight by dividing the number of cells in each population by the body weight (grams) of each mouse (n = 6). (C) Quantitation of normalized numbers of pre-cDC and pDC in the bone marrow of WT and Pin1-null mice. Normalized cell numbers were calculated as described in (B) (n = 6).