Immune-phenotype and bone marrow (BM) progenitor status of naïve <i>ngr1-/-</i> and WT mice.

<p>(<b>A</b>) Comparative flow cytometric analysis of single cell suspension from spleen, BM, thymus, blood, lymph nodes and central nervous system (CNS) associated mononuclear cells. Proportion and total number of CD3⁺CD8⁺ and CD3⁺CD4⁺ T cells, B220⁺ B cells, Gr-1⁺ granulocytes and F4/80 (Gr-1^loF4/80⁺) monocyte/macrophage are shown. Data represent mean ± SEM (n = 8-11). *p&lt;0.05 Mann-Whitney test. (<b>B</b>) Quantification of BM-derived colony number in naïve <i>ngr1-/-</i> and WT mice<b>.</b> After 8 days on methylcellulose culture, BM-derived progenitors from <i>ngr1-/-</i> animals were capable of producing granulocytes (G); macrophages (M) and mixed (GM) colonies at comparable numbers to WT mice. Bars represent mean colony number/plate ± SEM (n = 3).