Dose responses, less-than-additive response domains, and greater-than-additive response domains predicted for the synthetic promoters studied by Joung et al. (1993).

<p>Solid lines labeled ‘F’ and ‘N’ were computed from Eq. (82) of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034439#pone.0034439.s001" target="_blank">Text S1</a> and represent predicted dose responses for the ‘far’ and ‘near’ single binding site promoters, respectively, of the Joung et al. study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0034439#pone.0034439-Joung1" target="_blank">[5]</a>. The dashed line indicates the sum of the activities of the single binding site promoters. The solid line labeled ‘F+N’ was computed from Eq. (25) and corresponds to the predicted dose response of the double binding site promoter. The diamond indicates the critical transcription factor dose obtained numerically from the intersection of the dashed graph with the ‘F+N’ graph. Parameters: see text.