<i>Mrp14^−/−</i> mice show enhanced hepatocellular injury during pneumonia derived sepsis caused by <i>Klebsiella</i>.

<p>Representative slides of liver haematoxylin and eosin HE staining of Wt (A) and <i>mrp14^−/−</i> mice (B) 48 hours post infection. Livers from <i>mrp14^−/−</i> mice displayed more advanced liver necrosis (#) accompanied with (micro) abscesses (<$>\vskip -1pt\scale 70%\raster="rg1"<$>). Arrows indicate fibrin deposits as a sign of thrombosis. Scalebar indicates 0.5 mm. Total pathology score was determined at indicated time points in Wt (grey) and <i>mrp14^−/−</i> mice (white) according to the scoring system described in the Methods section (C). Aspartate aminotransferase (AST) (D), alanine aminotransferase (ALT) (E), and lactate dehydrogenase (LDH) (F) were measured in plasma. Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (8 mice per group at each time point). *p<0.05, **p<0.01 versus Wt mice at the same time point.