TM^pro/pro mice show increased hepatocellular injury during experimental melioidosis.

<p>Mice were inoculated intranasally with 750<i>B. pseudomallei</i> and sacrificed after 24, 48 and 72 hours. Plasma levels of ASAT (A) and ALAT (B) after infection with <i>B. pseudomallei</i>. Data are expressed as box and whisker plots showing the smallest observation, lower quartile, median, upper quartile and largest observation. Grey boxes represent WT mice, white boxes represent TM^pro/pro mice (<i>n</i> = 8 mice/group). *<i>P</i><0.05 and **<i>P</i><0.01 for the difference between WT and TM^pro/pro mice (Mann-Whitney <i>U</i> test). ASAT aspartate aminotranspherase, ALAT alanine aminotranspherase.