Heatmap of log expression values.
- Christin Klenke (109284)
- Sebastian Janowski (109287)
- Daniela Borck (109289)
- Darius Widera (30596)
- Jörg Ebmeyer (109293)
- Jörn Kalinowski (23807)
- Anke Leichtle (109297)
- Ralf Hofestädt (109299)
- Tahwinder Upile (66807)
- Christian Kaltschmidt (30599)
- Barbara Kaltschmidt (30598)
- Holger Sudhoff (109301)
Publication date
December 2012
DOIAbstract
<p>For the heatmap generation, significantly regulated genes with a fold change of five were used. 116 up-regulated and 29 down-regulated genes are shown. The clustering reveals that the mRNA profiles of control samples (EAS1-EAS7) show differences to cholesteatoma samples (Chole1-Chole7) relating to the expression of inflammation related genes such as metalloproteinases (e.g. MMP9). The strong co-expression of MMP9 and its known substrate SPP1 (osteopontin 9) might be important. Furthermore, there was a group of patients with low expression of both MMP9 and SPP1, but high expression of genes such as S100A and GJB2.</p
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