Genome-wide clustering of T-PLL and normal control expression profiles.

Heatmap representing z-score-scaled expression measurements of 17,970 genes of each sample highlighting reduced (blue), unchanged (grey), and increased (red) expression of each gene in a specific sample in comparison to all other samples. T-PLL and normal control samples (columns) were clustered based on the similarity of their expression profiles and their corresponding gene-specific expression values are visualized (rows). The column dendrogram above the heatmap represents the clustering of individual samples defining four major subgroups: healthy control subcluster (red) and three T-PLL subclusters (blue: SG1, green: SG2, orange: SG3) as shown in the annotation column ‘subgroups’ below the dendrogram. Additional annotation columns contain further patient-specific meta-information: pretreatment before sample acquisition (brown: no, yellow: yes), TCL1A gene activity status based on immunophenotypic protein expression (pink: positive, violet: negative, grey: weak, white: NA), disease stage (light blue: active, dark blue: inactive, white: NA), age (range from light—32 years—to dark yellow—78 years, white: NA), and sex (light green: male, dark green: female, white: NA). Individual samples names are shown in the corresponding columns below the heatmap and the dendrogram left to the heatmap represents the clustering of genes.