Tumor endothelium-derived genes are expressed in multiple human diseases of chronic inflammation.

<p>Expressional clustering of human orthologs of the tumor endothelium-derived genes in patient tissue samples of (A) cirrhosis (153 genes), (B) inflammatory bowel disease (IBD) (140 genes), and (C) rheumatoid arthritis (RA) (106 genes) compared to normal tissue controls. Within the cluster diagram, each column represents a patient sample and each row represents a differentially expressed gene. Diseased samples are denoted by black hatches. Expression is depicted as mean-normalized, log2-transformed values. (D) Forty-nine genes were mutually dysregulated in the datasets tested and concordant in expression with the experimental model. (E) Pathway analysis of the 49-gene set demonstrating significant over-representation of several inflammation-related pathways. P-values were calculated using Fisher's exact test. Red line indicates p = 0.05.