Histological findings of wound tissue.

<p>Sections with hematoxylin and eosin staining were used to examine the re-epithelization of wounded skin in mice at 3 days (<b>A</b>) and 7 days (<b>B</b>) after surgery. A quantitative analysis revealed significantly smaller wound widths in mice that received pneumonectomy (Surgery+PBS group) than mice that received a sham operation (Control+PBS group) 3 days after surgery (<b>A</b>). The administration of AMD3100 significantly extended the wound width in mice subjected to pneumonectomy (Surgery+AMD group, p<0.05 vs. Surgery+PBS group) but did not change in mice that received sham operations (Control+PBS group), 3 days after surgery. There was no difference in the wound width among the groups at 7 days after treatment (<b>B</b>).