Wound healing is retarded in mice lacking TRs.

<p>(<b>A</b>) Representative examples of wound closure in control and TR KO mice. Images were taken at the indicated times after wounding. (<b>B</b>) H&E staining 2 days after wounding. The black arrows indicate the end of the keratinocyte tongues. The main length of the tongues and the % of wound re-epithelialization are shown in the right panels. (<b>C</b>) 10 days after wounding BrdU positive cells were quantitated from histological sections at the wound edges in Wt and KO mice. Data are means ± SE. **, <i>P</i><0.01. (<b>D</b>) H&E staining of wounds at 10 days. The lower panels show a detail of H&E and picrosirius staining of the indicated areas. (<b>E</b>) Collagen fibers detected under polarized light of picrosirius staining in the unwounded tissue (left panels) and the wound centers (right panels).