Cutaneous wound healing in WT and ET-1^f/f; Tie-2-Cre (+) mice.

<p>(A) Representative wound closure in wild-type (WT) and ET-1^f/f; Tie-2-Cre (+) (KO) mice at days 0, 5, 7, 10 post-wounding. (B) Hematoxylin-Eosin (HE) staining of wound tissues derived from wild-type (WT) and ET-1^f/f; Tie-2-Cre (+) (KO) mice at days 3, 7, 12 post-wounding. Arrow heads indicated bilateral edges of wound granulation tissue. Double-headed arrows indicated the distance between the leading edges of wounded epidermis. The one representative result is shown. Scale bar = 1000 µm. (C) Measurements of granulation tissue size (the distance between the arrow heads) in the wild-type (WT) and ET-1^f/f; Tie-2-Cre (+) (KO) mice at days 3, 7, 12 post-wounding. Data are expressed as the mean ± SD of six independent experiments. *<i>P</i><0.05 as compared with the value in WT mice. (D) Measurements of epithelial gap (the distance of double-headed arrows) in the wild-type (WT) and ET-1^f/f; Tie-2-Cre (+) (KO) mice at days 3, 7, 12 post-wounding. Data are expressed as the mean ± SD of six independent experiments. *<i>P</i><0.05 as compared with the value in WT mice.