The dermal thickness and collagen amount are greater in E2F1^–/– mice than in WT mice.

<p>Wound tissues were isolated at day 7 post-surgery and analyzed histologically. (A-B) H.E. and (C) Masson’s trichrome staining. Both entire wound (A) and wound border zone (B-C) are shown. Arrowheads indicate edges of wound granulation tissue. Double-headed arrow bars indicate the distance between the leading edges of wounded epidermis. (D) Quantifications of Epithelial gap (<i>left panel</i>), dermal thickness (<i>middle panel</i>), and collagen deposition (<i>right panel</i>). <b>**</b>p<0.01, <b>*</b>p<0.05; n = 10 per group.