CPEE reduces airway hyperresponsiveness (AHR) by OVA-challenge.

<p>AHR was measured using plethysmography 24 h after the final OVA challenge, in mice given various doses of methacholine (6.25–25 mg/mL). NC; normal control mice treated with PBS only; OVA; OVA-sensitized/challenged mice; Mon; Montelukast (30 mg/kg) + OVA-sensitized/challenged mice; CPEE-2; CPEE (200 mg/kg) + OVA-sensitized/challenged mice. Values are expressed as mean ± SD (n = 6/group). *Significantly different from NC, <i>P</i><0.05; †significantly different from OVA, <i>P</i><0.05.