The treatment of allergic mice with PPY alleviates development of airway hyper-responsiveness (AHR).

<p>Twenty-four hours after the final intranasal CKA or PBS administration, to evaluate the inhibitory effect of PPY on airway hyper-responsiveness, whole body barometric plethysmographic analysis was performed. The mice were stimulated with increasing does of aerosolized methacholine (0, 25, 50 and 100 mg/ml). Normal control mice treated with PBS only (NC), CKA-challenged mice treated with PBS (CKA), CKA-challenged mice treated with 10 mg/kg Montelukast (MK), CKA-challenged mice treated with 1 mg/kg PPY (PPY 1), CKA-challenged mice treated with 2 mg/kg PPY (PPY 2) and CKA-challenged mice treated with 10 mg/kg PPY (PPY 10).The data are represented as the mean ± S.E.M. of 6 mice. Statistical analysis was conducted by one-way ANOVA followed by the Newman-Keuls Multiple Comparison test (significantly different from NC, <i>*P</i><0.05, **<i>P</i><0.01, ***<i>P<</i>0.001; significantly different from CKA, <i>#P</i><0.05, ##<i>P</i><0.01, ###<i>P<</i>0.001, n = 6).