Motor coordination was assessed using the footprint, rotating rod, and hind-limb extension tests.

<p>The footprint test was used to examine the walking pattern (A, B). The <i>tottering-6j</i> strain including <i>6j</i>/<i>6j</i> (<i>n = </i>15), <i>6j</i>/+ (<i>n = </i>15), and +/+ mice (<i>n = </i>15), and the <i>rolling Nagoya</i> strain including <i>rol</i>/<i>rol</i> (<i>n = </i>15), <i>rol</i>/+ (<i>n = </i>15), and +/+ mice (<i>n = </i>15) were used (A). The heterozygous mice including <i>6j</i>/<i>rol</i> (<i>n = </i>15), <i>6j</i>/<i>+</i> (<i>n = </i>15), <i>rol</i>/+ (<i>n = </i>15), and +/+ (<i>n = </i>15) mice were used (B). In the rotating rod test, retention time on the rotating rod was examined in <i>6j</i>/<i>6j</i> (<i>n = </i>10), <i>6j</i>/+ (<i>n = </i>10), and +/+ mice (<i>n = </i>10) (C). In the hind-limb extension test, hind-limb posture was scored as 2, 1, or 0 (D), and the score for each strain is presented (E) for <i>6j</i>/<i>6j</i> (<i>n = </i>10), <i>6j</i>/+ (<i>n = </i>10), and +/+ mice (<i>n = </i>10). **<i>P</i><0.001 compared to the appropriate control (Tukey's test).