Decreased motor coordination deficits in <i>Cln6^nclf</i> mice.

<p><b>(A)</b> Rotarod testing was performed on postnatal day 14, 28, 90, and 270 old WT and <i>Cln6^nclf</i> mice. Data are plotted as average latency to fall from the rotating rod during a 240 second trial period (3 trials per mouse per time point). <i>Cln6^nclf</i> mice had a significant reduction in their ability to remain on the rod as it accelerated, starting at P90 and continuing at P270. <b>(B–C)</b> At six months of age, no difference was noted in additional motor performance measures including the time required to descend in a pole climb test <b>(B)</b> or the mean distance traveled (in meters) over a 15-min test period in an open field activity test <b>(C)</b>. [Mean +/− SEM, <i>n</i> = 6–9 mice per group (**<i>p</i>≤0.01, ***<i>p</i>≤0.0001)].