GPR55 KO mice have impaired motor coordination.

<p>(<b>A</b>) Summary for the novelty-induced locomotion measured in an open field assay. Horizontal activities were measured as total distance traveled. (<b>B</b>) Motor skill learning and coordination was assessed in the accelerating rotarod test. The time spent walking on top of the rotarod (latency to fall) for two consecutive days is shown for GPR55 KO mice and their WT littermates. There was a significant difference between genotypes (Day 1: t₆₁ = 3.061, p = 0.003; Day 2: t₆₁ = 2.569, p = 0.013; Student’s t-test), with GPR55 KO mice performing worse than their littermate controls for both days. (<b>C</b>) GPR55 KO mice made significantly more mistakes (footslips) while walking on parallel rods compared to littermate controls. *p<0.05; **p≤0.01.