BrdU labelled surviving cells in the dentate gyrus (DG) of wildtype (WT) and G93A mice subject to treadmill running (EX) or sedentary lifestyle (SED).

<p>(A) A representative image showed that most surviving cells in WT mice were located in the DG, with more rounded nuclei, sometimes with the typical chromation structure of granular cells (insert). Representative images showed surviving cells in WT sedentary mice (B) and G93A sedentary mice (C). (D).G93A mice had 30.1% more surviving cells than WT mice collapsed across sex. *G93A-SED>WT-SED, P = 0.017, n = 10–12 per group. (E). WT-EX mice collapsed across sex had 29.1% more surviving cells than WT-SED mice. † WT-EX>WT-SED, P = 0.028., n = 10–12 per group. (F). Male G93A mice had 22.4% fewer surviving cells than female G93A mice (‡ G93A-MΨ G93A-Male-EXG93A-Female-SED, P = 0.057), n = 10 per group except for G93A-SED females = 11. Data are means ± SEM. Scale bar = 25 µm in A, 100 µm in B,C.