Cell proliferation and survival in the dentate gyrus.

<p>Mean values ± SEM. (A, B) MaLPA₁-null mice showed defective cell proliferation as assessed by BrdU (A) and PCNA (B) immunolabeling. Notably, the number of proliferating cells was reduced by chronic stress only in the mutant genotype. (C) Chronic stress reduced the survival of new cells labelled with BrdU prior to stress treatment, but cell survival was similar between genotypes when data were corrected for their distinct proliferation rates. (- %): reduction from the control group. Scale bar in A (also valid for B and C): 100 µm; 20 µm. Arrows indicate cells positive for BrdU (A) and PCNA (B). Post-hoc LSD tests: (*<i>p</i><.05; **<i>p</i><.001): significant difference between the stressed group vs. its control; (#<i>p</i><.05; ##<i>p</i><.001): significant difference between the control NULL vs. the control WT mice.