Cell proliferation and survival.

<p>(A) Quantification of the number of Ki67-positive cells in the subgranular zone (SGZ) of the dentate gyrus. The DIAB-EE group showed an increase compared with the DIAB-SC group (* <i>p</i><0.05; <i>post hoc</i> test <i>p</i>>0.05 for every other group pair comparison) (B) Quantification of the number of BrdU-positive cells in the SGZ and granular cell layer (GCL) of the dentate gyrus labeled 10 days after the BrdU injection. The DIAB-SC group showed a decrease in the BrdU-positive cell survival compared with the CTL-SC (* <i>p</i><0.05). An increase was found in the DIAB-EE group (# <i>p</i><0.05 vs. DIAB-SC). (C) Representative microphotographs of the dentate gyrus with anti-BrdU immunohistochemistry. The inset in (A) shows a high magnification view of a cluster of BrdU-positive cells in the SGZ. Scale bar corresponds to 100 µm.