The expression of BDNF mRNA in the DG of WT and G93A mice subject to treadmill running (EX) or sedentary lifestyle (SED).

<p>A representative autoradiograph showed BDNF mRNA hybridization signal in the DG in G93A mice (B) was stronger than that in WT mice (A). (C) G93A-SED mice had higher expression of BDNF mRNA by 15.5% than WT-SED mice. * G93A-SED>WT-SED, P = 0.016, n = 10–13 per group. (D) Exercised WT mice had significantly higher BDNF mRNA expression by 7.4% vs WT-SED mice. † WT-EX>WT-SED, P = 0.05, n = 11–12 per group. (E)There was no significance between G93A-EX and G93A-SED mice, n = 10–13 per group. Data are means ± SEM. Red arrows indicated BDNF mRNA hybridization signal in the DG.