MOG mimicked long-term exposure to glucose and FA by stimulating basal insulin secretion from pancreatic islet cells.

<p>A. Long-term exposure to 11 mM glucose and either 0.16 mM or 0.3 mM oleate complexed to FBS (FA) increased basal (2 mM glucose, white bars) and decreased glucose-stimulated insulin release (12 mM glucose, shaded bars) from INS-1 832/13 cells. MOG stimulated basal insulin secretion from dissociated rat islets in a concentration-dependent manner (25–400 µM) (B). C. Perifusion of rat islets demonstrated the pattern of MOG-stimulated basal insulin secretion. Arrow indicates addition of 200 µM MOG to 3 mM glucose. A and B. n = 12 from 3 separate experiments. C. Representative of 3 separate experiments. A and B, *p<0.005 compared to control.