Normal presynaptic function of hippocampal CA3-CA1 synapses in Pfn1^{flx/flx,CaMKII-cre} mice.

<p>(<b>A</b>) Basal synaptic transmission, as deduced from input-output curves, was normal in Schaffer-collateral-CA1 synapses of Pfn1^{flx/flx,CaMKII-cre} mice (n = 15 for controls and 10 for mutants). (<b>B</b>) In Pfn1^{flx/flx,CaMKII-cre} mice, no changes were found in paired-pulse ratios (PPR; n = 14 for controls, n = 17 for mutants) at various inter-stimulus intervals (ISI; 10–200 ms). Cumulative curves of amplitudes (<b>C</b>) and inter-event intervals (IEI) of mEPSCs (<b>D</b>) were virtually equal between genotypes (n = 8 in each group). Insets in C and D depict mean values.