Bidirectional unitary postsynaptic responses at PV → PYR synapses are normal in Nlgn3^R451C mice.

<p>A) Simplified schematic of a PV → PYR synapse. B) Representative traces averaged from 20 consecutive sweeps (including failures). A short 20 Hz train of 5 action potentials is elicited from the presynaptic PV interneuron (in voltage clamp, top) and unitary IPSC (uIPSCs) are recorded from the postsynaptic pyramidal neuron (WT = middle; Nlgn3^R451C = bottom). Scale bars: 500 pA (PV), 25 pA (PYR); 25 ms. C) Scatter plot of uIPSC1 amplitude for each connected pair from WT (<i>n</i> = 34) and Nlgn3^R451C (<i>n</i> = 29). D) Scatter plot of uEPSC1 of connected PYR → PV pairs showing no difference in excitatory transmission onto PV interneurons between WT (<i>n</i> = 19) and Nlgn3^R451C (<i>n</i> = 12).