Wobbler mice do not exhibit presynaptic impairments.

<p>(A) fEPSPs recorded during train stimulation of the Schaffer collaterals, in control mice at P17-P21. Arrows illustrate the pulses employed for the analyses: the slopes of the first three and the last three pulses (pulses 1, 2, 3, 8, 9, and 10 for the types of trains consisting of 10 pulses, and pulses 1, 2, 3, 198, 199, and 200 for the types of trains consisting of 200 pulses) from each type of train were normalized to the slope of the first pulse in the given trains. (B-E) No physiologically relevant differences were observed in short-term synaptic plasticity when comparing wobbler mice and control littermates during the presymptomatic phase (comparing B to C) or the symptomatic phase (comparing D to E). However, a few results reached statistical significance when testing the trains of the same intensity in wobbler mice against controls, as indicated by * (P<0.05) or ** (P<0.01) in the figure (C compared to B) (t-test). Note the shifts in pulse number. (P17-P21: control: n = 5 slices/4 mice, wobbler: n = 6 slices/6 mice. P45-P60: control: n = 10 slices/6 mice, wobbler: n = 9 slices/7 mice). Error bars represent SEM.