Synaptic deficits present in the CA1 region of A53T mice as early as 2 months.

<p>Field potentials were evoked by stimulating the Schaffer collaterals with a concentric bipolar electrode and recorded with glass electrodes in the stratum radiatum of CA1. Basal synaptic transmission is significantly impaired in 2 month A53T mice compared to wild type littermates (A). Paired-pulse facilitation (PPF) is significantly enhanced in 2 month-old A53T mice (B). Theta burst stimulation (TBS) induces LTP similarly in 2 month-old wild type and A53T mice (C). Low frequency stimulation (LFS, 900 pulses at 1 Hz) induces short and long term depression in wild type mice; however, it induces both short and long term potentiation in A53T mice (D). Data plotted as Mean+/− SEM. fEPSP = Field Excitatory Post-Synaptic Potentials, mV = millivolts, min = minutes.