<p>For all simulations: . Panel A: Effect of sample size assuming transcribed and <i>cis</i> acting polymorphism are in linkage equilibrium (Simulation parameters: and ). Panel B: The influence of the extent of disequilibrium (Simulation parameters: ); Panels C and D: The influence of effect size (Panel C for and panel D for other simulation parameters ). Panels E and F: The influence of allele frequency for the transcribed polymorphism (Panel E for and panel F for , othersimulation parameters: ). Panels G and H: The influence of allele frequency for the <i>cis</i> acting variant (Panel G for and Panel H for ,other parameters: ).</p
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
Generally, larger sample size leads to a greater statistical power to detect a significant differenc...
Genome wide association studies frequently reveal associations between disease susceptibility and po...
<p>Power comparison for different approaches at the 5% and 1% levels of significance for simulation ...
<p>The graph represents the influence of the number of sites upon the power to detect the SNP with t...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>The first panel corresponds to simulation scenario 1 using the LD structure of the DRD2 gene and ...
<p><b>Panel A</b> shows the simulated power for the sex-stratified model, <b>Panel B</b> shows the p...
Background: Spurious associations between single nucleotide polymorphisms and phenotypes are a major...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>Left panel: Power versus relative risk ratio (RRR) for different sample sizes, minor allele frequ...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
Generally, larger sample size leads to a greater statistical power to detect a significant differenc...
Genome wide association studies frequently reveal associations between disease susceptibility and po...
<p>Power comparison for different approaches at the 5% and 1% levels of significance for simulation ...
<p>The graph represents the influence of the number of sites upon the power to detect the SNP with t...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>The first panel corresponds to simulation scenario 1 using the LD structure of the DRD2 gene and ...
<p><b>Panel A</b> shows the simulated power for the sex-stratified model, <b>Panel B</b> shows the p...
Background: Spurious associations between single nucleotide polymorphisms and phenotypes are a major...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>Left panel: Power versus relative risk ratio (RRR) for different sample sizes, minor allele frequ...
<p>The true positive rate (TPR, row 1), false discovery rate (FDR, row 2) and false positive rate (F...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
Generally, larger sample size leads to a greater statistical power to detect a significant differenc...