<p>In the first row, we compare power of the three methods for different values of heritability under the three disease models while <i>μ</i> = 2 and the number of markers selected at the first stage is 10. In the second row, we compare power of the three methods for different numbers of markers selected at the first stage under the three disease models while <i>μ</i> = 2 and heritability is 0.05. In the third row, we compare power of the three methods for different values of <i>μ</i> under the three disease models while heritability is 0.05 and the number of markers selected at the first stage is 10. In each case, we use 800 genomic markers to control for population stratification in the admixture screening test.</p
20 simulated datasets for 3,000 individuals over different heritability (h2) and dominance ratio (d...
<p>The total number of phenotypes is <i>K</i> = 8, <i>c</i><sup>2</sup> = 0.5, <i>ρc</i><sup>2</sup>...
<p>The <i>Latent</i> column is the power with the proposed method applied to 6 latent phenotypes. Th...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
Background: There are two major classes of genetic association analyses: population based and family...
Background: There are two major classes of genetic association analyses: population based and family...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>For all simulations: . Panel A: Effect of sample size assuming transcribed and <i>cis</i> acting ...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>Various settings for the cost ratio of molecular haplotyping to genotyping <i>(r)</i> and the pro...
20 simulated datasets for 3,000 individuals over different heritability (h2) and dominance ratio (d...
<p>The total number of phenotypes is <i>K</i> = 8, <i>c</i><sup>2</sup> = 0.5, <i>ρc</i><sup>2</sup>...
<p>The <i>Latent</i> column is the power with the proposed method applied to 6 latent phenotypes. Th...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
Background: There are two major classes of genetic association analyses: population based and family...
Background: There are two major classes of genetic association analyses: population based and family...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>For all simulations: . Panel A: Effect of sample size assuming transcribed and <i>cis</i> acting ...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>Various settings for the cost ratio of molecular haplotyping to genotyping <i>(r)</i> and the pro...
20 simulated datasets for 3,000 individuals over different heritability (h2) and dominance ratio (d...
<p>The total number of phenotypes is <i>K</i> = 8, <i>c</i><sup>2</sup> = 0.5, <i>ρc</i><sup>2</sup>...
<p>The <i>Latent</i> column is the power with the proposed method applied to 6 latent phenotypes. Th...