<p>In the first row, we compare power of the three methods for different values of heritability under the three disease models while sample size is 600 trios and the number of markers selected at the first stage is 10. In the second row, we compare power of the three methods for different numbers of markers selected at the first stage under the three disease models while sample size is 600 trios and heritability is 0.05. In the third row, we compare power of the three methods for different sample sizes under the three disease models while heritability is 0.05 and the number of markers selected at the first stage is 10. In each case, we use 800 genomic markers to control for population stratification in the admixture screening test.</p
Background: There are two major classes of genetic association analyses: population based and family...
Background: There are two major classes of genetic association analyses: population based and family...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>For all simulations: . Panel A: Effect of sample size assuming transcribed and <i>cis</i> acting ...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>Various settings for the cost ratio of molecular haplotyping to genotyping <i>(r)</i> and the pro...
<p>The <i>Latent</i> column is the power with the proposed method applied to 6 latent phenotypes. Th...
<p>The total number of phenotypes is <i>K</i> = 8, <i>c</i><sup>2</sup> = 0.5, <i>ρc</i><sup>2</sup>...
Background: There are two major classes of genetic association analyses: population based and family...
Background: There are two major classes of genetic association analyses: population based and family...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of ite...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
<p>For all simulations: . Panel A: Effect of sample size assuming transcribed and <i>cis</i> acting ...
<p>Data were simulated based on real data by random selection of 1, 5 or 10 genotyped SNPs at either...
<p>(A) QQ plot of -log10 p values from SNP set tests using different SNP weights under the null simu...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>Various settings for the cost ratio of molecular haplotyping to genotyping <i>(r)</i> and the pro...
<p>The <i>Latent</i> column is the power with the proposed method applied to 6 latent phenotypes. Th...
<p>The total number of phenotypes is <i>K</i> = 8, <i>c</i><sup>2</sup> = 0.5, <i>ρc</i><sup>2</sup>...
Background: There are two major classes of genetic association analyses: population based and family...
Background: There are two major classes of genetic association analyses: population based and family...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...