<p>Power of detection for the different 2-locus models. Power was estimated as the proportion of iterations in which the full model F test for the correct model had a value . Panel A shows results for simulations with disparate allele frequencies within each locus (1%–10% for the rare allele and 90% for the other allele); panel B shows results for simulations with allele frequencies within each locus closer to equal (20%–30% for one allele and 70%–80% for the other allele). Sample sizes were 100, 500, or 1000 diploid individuals.</p
Abstract Background Phenome-wide association studies (PheWAS) are a high-throughput approach to eval...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p><b>A</b>) Statistical power was examined on a trait simulated from 27 causative mutations (QTNs) ...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
Simulation was used to study the power of detection of a fairly young (mutation occurred 50 generati...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>The calculated power with varying degrees of genetic heterogeneities (<i>R</i>) ranging from 0.01...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
Power is a function of effect size (relative to phenotypic standard deviation), sample size, noise r...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
A sample size with sufficient statistical power is critical to the success of genetic association st...
The power of a statistical test is the probability that it will yield a statistically significant re...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
Abstract Background Phenome-wide association studies (PheWAS) are a high-throughput approach to eval...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p><b>A</b>) Statistical power was examined on a trait simulated from 27 causative mutations (QTNs) ...
<p>A-D, KW, MLM and LM. The “Power” was defined as the detection frequency in 500 repeats for a cert...
<p>The power of the different methods to detect a QTN using a 5% significance level (based on the ob...
<p>500 simulations were based on haplotype distribution for each of 13 deep sequenced candidate gene...
Simulation was used to study the power of detection of a fairly young (mutation occurred 50 generati...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p>The calculated power with varying degrees of genetic heterogeneities (<i>R</i>) ranging from 0.01...
<p>Power is measured across one hundred simulations of phenotypic effects at each of 24 human gene l...
Power is a function of effect size (relative to phenotypic standard deviation), sample size, noise r...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
A sample size with sufficient statistical power is critical to the success of genetic association st...
The power of a statistical test is the probability that it will yield a statistically significant re...
<p>Power estimates for BOMP, VT, SKAT, KBAC (KBAC1P = minor allele frequency defined as , KBAC5P = m...
Abstract Background Phenome-wide association studies (PheWAS) are a high-throughput approach to eval...
<p>In the first row, we compare power of the three methods for different values of heritability unde...
<p><b>A</b>) Statistical power was examined on a trait simulated from 27 causative mutations (QTNs) ...