Single-SNP power calculations for different statistical models for X-linked markers.

<p><b>Panel A</b> shows the simulated power for the sex-stratified model, <b>Panel B</b> shows the power for the model without X-inactivation in females, and <b>Panel C</b> shows the power for the model with X-inactivation. The plots on the left-hand side display power simulations with increasing relative risks and varying sample sizes of case-parent triads, assuming a SNP minor allele frequency (MAF) of 0.2. The plots on the right-hand side show the simulated power with increasing relative risks and MAFs, assuming 600 case-parent triads in the study population (300 case-parent triads for the sex-stratified model). A significance level of 0.05 was used.