<p>A. NCX function was measured as the tail current upon repolarization to −70 mV (arrow) after a step to +10 mV in CTRL and MI. B. Averaged NCX current density in CTRL (N<sub>pigs</sub> = 9, n<sub>cells</sub> = 30) and MI (N<sub>pigs</sub> = 7, n<sub>cells</sub> = 19), with [Ca<sup>2+</sup>]<sub>i</sub> measured simultaneously. * denotes P<0.05.</p
Mitochondrial membrane potential (ΔΨm) arises from normal function of the electron transport chain. ...
<p>A, The activity of NCX was probed in reverse mode by monitoring the rise of Ca<sup>2+</sup><sub>i...
<p>Whole-cell patch-clamp recordings were taken from individual murine cardiomyocytes isolated from ...
<p>The protocol was adapted from Hobai <i>et al</i> [<a href="http://www.plosone.org/article/info:do...
<p>(A) Voltage protocol used for measuring I<sub>NCX</sub>, the typical membrane currents obtained i...
<p>A. Example of current and [Ca<sup>2+</sup>]<sub>i</sub> transient recording obtained during the l...
<p><b>A.</b> Representative I<sub>Ca,L</sub> recordings in SAN myocytes in control conditions, in th...
<p>(A) Current traces recorded at -100 mV from oocytes expressing NvHCN1 or NvHCN2 before (black) an...
<p><b>Panel A</b>. Original Ni<sup>2+</sup>-sensitive (NCX) current traces before and after superfus...
<p>A. Spark frequency, and, B, duration in early vs. delayed release areas in MI, with the MI-depend...
<p>A, The first portion of the trace shows Ca<sup>2+</sup> channel activity at <i>V</i><sub>m</sub>+...
<p><b>A</b>: Representative traces of whole-cell <i>I</i><sub>Ca</sub> recordings with 2 mM [Ca<sup>...
<p>A. Effect of NCX block by 5 mM nickel on spark frequency and duration in early (left) and delayed...
<p><i>A.</i> An inward current with a persistent component (arrow) recorded in a representative cell...
A. Original recordings of channel activity at different transmembrane voltages in I/O patches at 3 μ...
Mitochondrial membrane potential (ΔΨm) arises from normal function of the electron transport chain. ...
<p>A, The activity of NCX was probed in reverse mode by monitoring the rise of Ca<sup>2+</sup><sub>i...
<p>Whole-cell patch-clamp recordings were taken from individual murine cardiomyocytes isolated from ...
<p>The protocol was adapted from Hobai <i>et al</i> [<a href="http://www.plosone.org/article/info:do...
<p>(A) Voltage protocol used for measuring I<sub>NCX</sub>, the typical membrane currents obtained i...
<p>A. Example of current and [Ca<sup>2+</sup>]<sub>i</sub> transient recording obtained during the l...
<p><b>A.</b> Representative I<sub>Ca,L</sub> recordings in SAN myocytes in control conditions, in th...
<p>(A) Current traces recorded at -100 mV from oocytes expressing NvHCN1 or NvHCN2 before (black) an...
<p><b>Panel A</b>. Original Ni<sup>2+</sup>-sensitive (NCX) current traces before and after superfus...
<p>A. Spark frequency, and, B, duration in early vs. delayed release areas in MI, with the MI-depend...
<p>A, The first portion of the trace shows Ca<sup>2+</sup> channel activity at <i>V</i><sub>m</sub>+...
<p><b>A</b>: Representative traces of whole-cell <i>I</i><sub>Ca</sub> recordings with 2 mM [Ca<sup>...
<p>A. Effect of NCX block by 5 mM nickel on spark frequency and duration in early (left) and delayed...
<p><i>A.</i> An inward current with a persistent component (arrow) recorded in a representative cell...
A. Original recordings of channel activity at different transmembrane voltages in I/O patches at 3 μ...
Mitochondrial membrane potential (ΔΨm) arises from normal function of the electron transport chain. ...
<p>A, The activity of NCX was probed in reverse mode by monitoring the rise of Ca<sup>2+</sup><sub>i...
<p>Whole-cell patch-clamp recordings were taken from individual murine cardiomyocytes isolated from ...