<p><b>Panel A</b>. Original Ni<sup>2+</sup>-sensitive (NCX) current traces before and after superfusion of the cells with ORM-10962 at concentrations of 10 nM, 100 nM and 1 μM. <b>Panel B.</b> The drug-response curve of ORM-10962 on the outward (top) and inward (bottom) NCX currents in dog ventricular myocytes is given at 20 mV and at -80 mV, respectively. Values are means ± SEM. Numbers in brackets show the number of experiments for each data point.</p
<p>(A) Voltage protocol used for measuring I<sub>NCX</sub>, the typical membrane currents obtained i...
International audience1. The regulation of L-type Ca(2+) current (I(Ca)) by the two nitric oxide (NO...
The occurrence of early afterdepolarization (EAD) in single mouse ventricular myocytes was observed ...
<p>The protocol was adapted from Hobai <i>et al</i> [<a href="http://www.plosone.org/article/info:do...
<p><b>Panels A and B.</b> Original I<sub>K1</sub> (top) and I<sub>to</sub> (bottom) current traces (...
<p><b>Panel A.</b> Lack of effect of 1 μM ORM-10962 on the L-type I<sub>Ca</sub> in dog ventricular ...
Na+/Ca2+ exchanger (NCX) is the main Ca2+ transporter in cardiac myocytes. Its inhibition could be e...
<p><b>Panel A.</b> The effect of 1 μM ORM-10962 on the delayed afterdepolarization (DAD) amplitude i...
<p>A, <i>top</i>: Representative I<sub>to</sub> current traces under control conditions and after ap...
The effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse ...
INTRODUCTION: NS5806 activates the transient outward potassium current (I(to) ) in canine ventricula...
<p><b>A.</b> Representative I<sub>Ca,L</sub> recordings in SAN myocytes in control conditions, in th...
<p><i>Top</i> panel shows representative current traces, <i>bottom</i> panel represents current – vo...
<p>A. NCX function was measured as the tail current upon repolarization to −70 mV (arrow) after a st...
The mechanism for the reduction of the transient outward K+ current (Ito) in diseased myocardium is ...
<p>(A) Voltage protocol used for measuring I<sub>NCX</sub>, the typical membrane currents obtained i...
International audience1. The regulation of L-type Ca(2+) current (I(Ca)) by the two nitric oxide (NO...
The occurrence of early afterdepolarization (EAD) in single mouse ventricular myocytes was observed ...
<p>The protocol was adapted from Hobai <i>et al</i> [<a href="http://www.plosone.org/article/info:do...
<p><b>Panels A and B.</b> Original I<sub>K1</sub> (top) and I<sub>to</sub> (bottom) current traces (...
<p><b>Panel A.</b> Lack of effect of 1 μM ORM-10962 on the L-type I<sub>Ca</sub> in dog ventricular ...
Na+/Ca2+ exchanger (NCX) is the main Ca2+ transporter in cardiac myocytes. Its inhibition could be e...
<p><b>Panel A.</b> The effect of 1 μM ORM-10962 on the delayed afterdepolarization (DAD) amplitude i...
<p>A, <i>top</i>: Representative I<sub>to</sub> current traces under control conditions and after ap...
The effects of NCX knockout were determined in a variety of cardiac cell models. Those of the mouse ...
INTRODUCTION: NS5806 activates the transient outward potassium current (I(to) ) in canine ventricula...
<p><b>A.</b> Representative I<sub>Ca,L</sub> recordings in SAN myocytes in control conditions, in th...
<p><i>Top</i> panel shows representative current traces, <i>bottom</i> panel represents current – vo...
<p>A. NCX function was measured as the tail current upon repolarization to −70 mV (arrow) after a st...
The mechanism for the reduction of the transient outward K+ current (Ito) in diseased myocardium is ...
<p>(A) Voltage protocol used for measuring I<sub>NCX</sub>, the typical membrane currents obtained i...
International audience1. The regulation of L-type Ca(2+) current (I(Ca)) by the two nitric oxide (NO...
The occurrence of early afterdepolarization (EAD) in single mouse ventricular myocytes was observed ...