Inhibition of SCD activity with CVT-11127 impairs the proliferation of H460 cancer cells but not normal human fibroblasts.

<p>Cell growth was determined in AG01518 normal human fibroblasts (<b>A</b>) in presence of 1 and 2 µM CVT-11127 in 10%FBS DMEM or vehicle for 96 h. H460 cells (<b>B</b>) were treated with 1 µM CVT-11127 or vehicle for 96 h. Cell proliferation rate was assessed by Crystal violet staining. <b>*</b>, p<0.05 or less, vs DMSO; by Student's t test.