Dose-dependent inhibition of proliferation in SCC25 and SCC104 cells after treatment with PCT analogs.

<p>(A-D):48-h treatment with TM-025/TM-026 showed significant (P<0.0001; depicted with *) dose-dependent decrease in the levels of Ki67, a cell proliferation marker, in SCC25 (A and B) and SCC104 (C and D) cells. All experiments were performed in five replicates, and the results are presented as means (±SEM). (E-F): 48 h treatment with either of the PCT analogs exhibited a dose-dependent (0, 1, 10 and 50 nM) decrease in the percentage of actively proliferating (BrdU⁺) cells in SCC25 (E) and SCC104 (F) cells. Results were significant at P<0.0001 (<i>n</i> = 5), and depicted with *.