Frequency of Fixation of a Differentiation Knockout Mutant as a Function of Time

<p>The model was run for 500 timesteps to allow the cell populations to equilibrate before a mutant cell that could not differentiate was injected. Those mutant clones that did not go extinct in the next 100 timesteps expanded rapidly. Mutants injected into the stem cell compartment reached fixation more frequently than mutants injected into a TAC compartment. Each data point represents 500 trials with standard error bars.