<p>Frequency of fixation in nondifferentiating populations (filled circles), stem cells (triangles), and TACs (squares) with standard error bars. Because they did not vary, results for all three transient amplifying stages are pooled.</p
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
<p>The quantity , which corresponds to , is plotted as a function of the mutation rate, , for three ...
<p>We assume <i>N</i><sub>S</sub> = <i>N</i><sub>D</sub> = 10, , and <i>η</i><sub>1</sub> = <i>η</i>...
<p>Frequency of fixation when introduced into nondifferentiating populations (filled circles), stem ...
<p>Each data point represents 500 trials with standard error bars. Cells that cannot apoptose (morta...
<p>The model was run for 500 timesteps to allow the cell populations to equilibrate before a mutant ...
<p>Measurements are based on the phenotype of progenitors before cell septation and progeny immediat...
Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. His-torically, ...
<p>Measurements are based on the phenotype of progenitors and progeny before cell septation. 1–6 are...
<p>(Black) all patients, (red) patients in which mutation A arose and reached fixation (i.e. 100% fr...
<p>In the liver <b>(A)</b> and pancreas <b>(B)</b>, frozen sections were scored under a fluorescent ...
<div><p>Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Histori...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>(A) Typical simulation trajectory with dedifferentiation () for the same random number seed as <a...
<p>The median rate (95% confidence of intervals) of the different genome instability events was meas...
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
<p>The quantity , which corresponds to , is plotted as a function of the mutation rate, , for three ...
<p>We assume <i>N</i><sub>S</sub> = <i>N</i><sub>D</sub> = 10, , and <i>η</i><sub>1</sub> = <i>η</i>...
<p>Frequency of fixation when introduced into nondifferentiating populations (filled circles), stem ...
<p>Each data point represents 500 trials with standard error bars. Cells that cannot apoptose (morta...
<p>The model was run for 500 timesteps to allow the cell populations to equilibrate before a mutant ...
<p>Measurements are based on the phenotype of progenitors before cell septation and progeny immediat...
Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. His-torically, ...
<p>Measurements are based on the phenotype of progenitors and progeny before cell septation. 1–6 are...
<p>(Black) all patients, (red) patients in which mutation A arose and reached fixation (i.e. 100% fr...
<p>In the liver <b>(A)</b> and pancreas <b>(B)</b>, frozen sections were scored under a fluorescent ...
<div><p>Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Histori...
<p>The fastest pathway of both cases is DGR, but the probabilities of stem-cell division are markedl...
<p>(A) Typical simulation trajectory with dedifferentiation () for the same random number seed as <a...
<p>The median rate (95% confidence of intervals) of the different genome instability events was meas...
Background—Evolution depends on mutations: rare errors in the transmission of genetic information. E...
<p>The quantity , which corresponds to , is plotted as a function of the mutation rate, , for three ...
<p>We assume <i>N</i><sub>S</sub> = <i>N</i><sub>D</sub> = 10, , and <i>η</i><sub>1</sub> = <i>η</i>...
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