Three sets of initial conditions are described in the text. These converge to similar distributions in the long-time limit. Simulations were run for 100,000 time units and an average was taken over the second half of the simulation. Parameters: b = 10, c = 0.001, δt = 0.01, u = 0.0001, lattice: L = 1024x1024. The equilibrium concentration of S in these runs is close to 0.32.</p
<p>(A) Within each cell the concentrations of lactose, LacYZ and LacI are simulated, as well as the ...
<p>Total cellular population for a simulation of healthy epithelial tissue on 12,672 processing core...
<p> is the fraction of time points (between 300 min and 700 min) at which more than 95% or less than...
Each run begins with randomly positioned P, N and S cells with a concentration of 0.05 each. For all...
Mutations occur between P and N, and between S and R. Parameters: r1 = 2.0, r2 = 2.5, a = 110 b = 10...
<p>Parameter choices are , , and simulations were performed on a lattice. Trajectories are average...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
The blue (red) dots show the simulated concentration (copy number) distribution for the full model o...
<p>The model was run for 500 timesteps to allow the cell populations to equilibrate before a mutant ...
<p>These numbers were obtained by a simulation with the parameters set that gave the best fit to the...
<p>For each combination of <i>U</i> ( = 0.1, 0.3, and 0.5) and <i>s</i> ( = 0.01 and 0.1), simulatio...
<p>The model system was seeded with environments, at simulation temperatures of 0.10, 0.30, 0.40, or...
<p>Environments, at simulation temperatures of 0.10, 0.30, 0.40, or 0.60, were seeded with 500 organ...
<p>The plots show the amount of signal that is present in a population of cells that evolved for 550...
<p><b>A, B, D, E)</b> Stochastic simulations for a population of 5000 cells in four different condit...
<p>(A) Within each cell the concentrations of lactose, LacYZ and LacI are simulated, as well as the ...
<p>Total cellular population for a simulation of healthy epithelial tissue on 12,672 processing core...
<p> is the fraction of time points (between 300 min and 700 min) at which more than 95% or less than...
Each run begins with randomly positioned P, N and S cells with a concentration of 0.05 each. For all...
Mutations occur between P and N, and between S and R. Parameters: r1 = 2.0, r2 = 2.5, a = 110 b = 10...
<p>Parameter choices are , , and simulations were performed on a lattice. Trajectories are average...
<p><b>A</b>: Results of a typical run at the exponential growth phase and at equilibrium (type A cel...
The blue (red) dots show the simulated concentration (copy number) distribution for the full model o...
<p>The model was run for 500 timesteps to allow the cell populations to equilibrate before a mutant ...
<p>These numbers were obtained by a simulation with the parameters set that gave the best fit to the...
<p>For each combination of <i>U</i> ( = 0.1, 0.3, and 0.5) and <i>s</i> ( = 0.01 and 0.1), simulatio...
<p>The model system was seeded with environments, at simulation temperatures of 0.10, 0.30, 0.40, or...
<p>Environments, at simulation temperatures of 0.10, 0.30, 0.40, or 0.60, were seeded with 500 organ...
<p>The plots show the amount of signal that is present in a population of cells that evolved for 550...
<p><b>A, B, D, E)</b> Stochastic simulations for a population of 5000 cells in four different condit...
<p>(A) Within each cell the concentrations of lactose, LacYZ and LacI are simulated, as well as the ...
<p>Total cellular population for a simulation of healthy epithelial tissue on 12,672 processing core...
<p> is the fraction of time points (between 300 min and 700 min) at which more than 95% or less than...