Glucose metabolism in the Fgl1 null mouse.

<p>A) <i>Fgl1^−/−</i> mice have fasting hyperglycemia (P = 0.005, n = 10 for <i>Fgl1^+/+</i> and n = 8 for <i>Fgl1^−/−</i>). B) Glucose tolerance tests of fasted 3 month old mouse. The graph represents a plot of plasma glucose versus time after i.p. administration of glucose. The superimposed panel represents plots of average area under the curve (AUC) for each mouse. The baseline was set as the mean pre-glucose administration plasma level. The difference is glucose levels as determined from the AUC is significant (P = 0.002, n = 4 per group). C) Insulin tolerance test on 3 month old fasted mouse shows a similar rate of decline of glucose levels between the <i>Fgl1^+/+</i> and <i>Fgl1^−/−</i> mice. AUC calculations after normalizing for baseline glucose for the first 45 min of the test shows no differences between Fgl1 containing and deficient mice (n = 5 per group). D) Insulin levels are not different between <i>Fgl1^+/+</i> and <i>Fgl1^−/−</i> mice. E) HOMA scores are not different for <i>Fgl1^+/+</i> and <i>Fgl1^−/−</i> (n = 5 for <i>Fgl1^+/+</i> and 4 for <i>Fgl1^−/−</i>). F) Graph of glucose levels following administration of pyruvate to fasted mice. Inset is AUC calculation which shows a difference in glucose levels over the duration of the experiment (P = 0.029, n = 5 per group).