FTO contributes to the development of hyperglycaemia.

<p>All data are elevated from female mice. *indicate significant p-values between <i>Lep^ob/ob;Fto^+/+</i>and <i>Lep^ob/ob;Fto^−/−</i>. a) Fasted glucose levels in mice at the age of 6 weeks (n = 13, 10, 12, 8) b) Non-fasted glucose level at the age of 7 weeks (n = 12, 9, 12, 9). c) Glucose tolerance test (GTT) at the age of 6 weeks (n = 13, 10, 12, 8). d) Insulin tolerance test (ITT) at the age of 7 weeks (n = 12, 9, 12, 9). Glucose values are presented relative to initial glucose levels. e) Fasted glucose levels in mice at the age of 14 weeks (n = 11, 7, 9, 9). f) Non-fasted glucose level at the age of 15 weeks (n = 11, 8, 14, 12). g) GTT at the age of 14 weeks (n = 11, 7, 9, 9). h) ITT at the age of 15 weeks (n = 11, 8, 14, 12). Glucose values are presented relative to initial glucose levels. i) Plasma glucose levels of 30 weeks old non fasted mice (n = 8, 5, 5, 6). j) Plasma insulin levels of non-fasted mice at the age of 30 weeks (n = 3, 3, 7, 3). All data are presented as mean. Error bars indicate the SEM.