<p>(A) FVB/NJ-<i>Ins2</i><sup>+/C96Y</sup> mice developed sustained hyperglycemia by 4 weeks of age, which persisted throughout the duration of the study. (B) Urine output in FVB/NJ-<i>Ins2</i><sup>+/C96Y</sup> was significantly increased by 8 weeks of age and further increased during the study period. Black bars = control (n = 6 to 8); white bars = Akita (n = 6 to 8). Data are mean ± SEM. *P<0.05 †P<0.001 or **P<0.01 vs. age-matched controls.</p
<p>Metabolic parameters including body weight, glucose and insulin levels were determined at the end...
<p>An age-dependent impairment in glucose handling was apparent in FATZO mice compared to control mi...
<p>All data are elevated from female mice. *indicate significant p-values between <i>Lep<sup>ob/ob</...
<p>(A) Kidney-to-body weight ratio was significantly increased in diabetic Akita mice (n = 6 to 8) c...
<p>(A) UAE was significantly elevated compared with controls in diabetic Akita mice by 8 weeks of ag...
<p><b><i>A</i></b>, Blood glucose in 2-, 4- and 6-mo-old wild-type (WT) and IDE-KO (KO) mice followi...
<p>(A,B) Fasting blood glucose (A) and insulin levels (B) in male non-progressing mice 30 weeks of a...
<p>(A) Random blood glucose levels in 2–16 weeks of age (n = 10–12). (B) Fasting blood glucose level...
<p>(A–E) Blood glucose was measured after an overnight fast (16 hr) or in random-fed states at the i...
<p>Controls, white bars or open circles; TgCEL mice, black bars or filled circles. Results are given...
<p>Body weight (<b>A</b>), random fed blood glucose levels (<b>B</b>), and fasting blood glucose lev...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
<p>A. Blood glucose levels of control and diabetic mice are shown as a function of time after the in...
<p>A. RIIβ<sup>−/−</sup> blood glucose levels were slightly lower than WT for both old males and fem...
<p>A) Weight increases significantly with age in <i>ob/ob</i>-luc mice consistent with the original ...
<p>Metabolic parameters including body weight, glucose and insulin levels were determined at the end...
<p>An age-dependent impairment in glucose handling was apparent in FATZO mice compared to control mi...
<p>All data are elevated from female mice. *indicate significant p-values between <i>Lep<sup>ob/ob</...
<p>(A) Kidney-to-body weight ratio was significantly increased in diabetic Akita mice (n = 6 to 8) c...
<p>(A) UAE was significantly elevated compared with controls in diabetic Akita mice by 8 weeks of ag...
<p><b><i>A</i></b>, Blood glucose in 2-, 4- and 6-mo-old wild-type (WT) and IDE-KO (KO) mice followi...
<p>(A,B) Fasting blood glucose (A) and insulin levels (B) in male non-progressing mice 30 weeks of a...
<p>(A) Random blood glucose levels in 2–16 weeks of age (n = 10–12). (B) Fasting blood glucose level...
<p>(A–E) Blood glucose was measured after an overnight fast (16 hr) or in random-fed states at the i...
<p>Controls, white bars or open circles; TgCEL mice, black bars or filled circles. Results are given...
<p>Body weight (<b>A</b>), random fed blood glucose levels (<b>B</b>), and fasting blood glucose lev...
<p>(A) Blood glucose levels (mg/dl) in fasted and ad-lib fed TG mice and their control littermates a...
<p>A. Blood glucose levels of control and diabetic mice are shown as a function of time after the in...
<p>A. RIIβ<sup>−/−</sup> blood glucose levels were slightly lower than WT for both old males and fem...
<p>A) Weight increases significantly with age in <i>ob/ob</i>-luc mice consistent with the original ...
<p>Metabolic parameters including body weight, glucose and insulin levels were determined at the end...
<p>An age-dependent impairment in glucose handling was apparent in FATZO mice compared to control mi...
<p>All data are elevated from female mice. *indicate significant p-values between <i>Lep<sup>ob/ob</...