Livers of RRV infected Ig-α ^-/- mice have decreased pro-inflammatory cells.

<p>(A) <u>Liver immune cell profile in 2 week old mice</u>. Immune cells were identified based on CD45 expression. Shown is the mean±SD absolute number of each immune cell subset per liver. CD3/4: * P<.01 vs. Ig-α-/- RRV; CD3/8: * P<.05 vs. WT RRV; #P<.01 vs. Ig-α-/- RRV; CD11b: * P<.001 vs. Ig-α-/- BSS; ** P<.001vs. WT BSS; #P < .05 vs. Ig-α-/- RRV; + P<.001 vs. WT RRV; B220: *P<.05 vs. Ig-α^-/- BSS; #P < .01 vs. Ig-α^-/- RRV; NKG2D: *P<.05 vs. Ig-α^-/- BSS; #P < .05 vs. WT BSS; +P < .01 vs. WT RRV; CD3/NKG2D: *P<.001 vs. WT RRV; #P < .001 vs. Ig-α^-/- RRV. (B) <u>Liver immunohistochemistry</u>. Liver tissue was incubated with anti-CD3 FITC (green-T cells), anti-CD11B FITC (green- macrophages), anti-cytokeratin 19 AF555 (red- bile ducts) and Hoechst nuclear dye (blue).